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Quantitative Measurement of Protein Dynamics with High Linearity Atomic Force Spectrometer

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The single molecule force spectrometer described in this paper uses of fast and highly linear piezo stage. This multi-axis stage (model P-313 PicoCube) can run in open loop and provide closed-loop linearity, but at higher dynamics. The linearity, bandwidth and comparative absence of hysteretic behavior for this multi-axis assembly ensure previously unattained resolution. Combined with a robust, simple, high-end design, this new generation of single molecule force-clamp instrumentation is ideally suited to capture the individual force-induced unfolding and folding trajectories of single protein molecules.

Quantitative Measurement of Protein Dynamics with High Linearity Atomic Force Spectrometer
Quantitative Measurement of Protein Dynamics with High Linearity Atomic Force Spectrometer

 

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PI (Physik Instrumente) is a leading manufacturer of precision motion control equipment, piezo motors, air bearing stages and hexapod parallel-kinematics for semiconductor applications, photonics, bio-nano-technology and medical engineering. PI has been developing and manufacturing standard & custom precision products with piezoceramic and electromagnetic drives for 4 decades. The company has been ISO 9001 certified since 1994 and provides innovative, high-quality solutions for OEM and research. PI is present worldwide with fifteen subsidiaries, R&D / engineering on 3 continents and total staff of more than 1,000.

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