In contrast to Super-Resolution Optical Microscopy, scanning ion conductance microscopy (SICM) does not require precision optics, instead an electrical probe tip is scanned. Like optical microscopy, SICM is also used for studying live cells and, for example, the interaction of nanoparticles with the cell membrane.
In the recently published article, “A Low-Cost, Large Field-of-View Scanning Ion Conductance Microscope for Studying Nanoparticle–Cell Membrane Interactions” by Gesper et al, a compact and affordable setup is described that can boost spatial resolution to 70 nanometers and below, while observing a rather large square area of 80 micrometers. The system consists of a compact P-611 NanoCube XYZ piezo nanopositioning stage and an additional fast P-111.05, high-speed piezo shear actuator, providing 5µm lateral motion, with 155kHz resonant frequency.
More information: Abstract of the article